Daniel Maluf, MD. FICS.

Virginia Commonwealth University Medical Center
Division of Transplantation Surgery
1200 East Broad Street, West Hospital
P.O. Box 980057, MCV Station
Richmond, VA 23298-0057
(804) 828-9314
(804) 828-5861 (FAX)
Email: dgmaluf@vcu.edu

LICENSURE AND CERTIFICATION:

Virginia Medical License No. 0116013448
Board Certification, Graduate School of Surgeons, Cordoba, Argentina License No. 23998
USMLE/ECFMG #0-567-276-1
Fellow International College of Surgeons.

EDUCATION:

POSTDOCTORAL TRAINING OR SPECIAL EXPERIENCE:

Virginia Commonwealth University Medical Center, Clinical Fellowship in
Transplantation Surgery, 2001-2002
Virginia Commonwealth University Medical Center, Research Fellowship
Transplantation Surgery, 2000-2001(Hepatocyte Transplantation)
Hospital Privado, 1995-2000
Chief Resident, ( Laparoscopy Instructor) 1999-2000
Surgery Resident, 1996-1999
Internship in Internal Medicine, 1995-1996
Internship in General Surgery, 1994-1995

ACADEMIC APPOINTMENTS/OTHER WORK EXPERIENCE:

Co-Director, Hume-Lee Hepatocellular Carcinoma Program
Division of Transplantation Surgery
Medical College of Virginia Hospitals
Virginia Commonwealth University Medical Center
Richmond, Virginia
01/04 – present

Director of Educational Activities
Division of Transplantation Surgery
Medical College of Virginia Hospitals
Virginia Commonwealth University Medical Center
Richmond, Virginia
01/04 – present

Assistant Professor of Surgery
Department of Surgery
Division of Transplantation Surgery
Medical College of Virginia Hospitals
Virginia Commonwealth University Medical Center
Richmond, Virginia
2002 – present

Attending Surgeon
Medical College of Virginia Hospitals
Virginia Commonwealth University Medical Center
Richmond, Virginia
2002 - present

Instructor: Laparoscopic Surgery
Foundation for the Progress of the Medicine
Cordoba, Argentina
1998-1999

MEMBERSHIP – SCIENTIFIC, HONORARY AND PROFESSIONAL SOCIETIES:

International College of Surgeons, 2005
Argentina Society of Transplant, 2003
American Society of Transplant Surgeons, 2003
American Society of Transplantation, 2001

SPECIAL AWARDS, FELLOWSHIPS AND OTHER HONORS:

Awards
David Hume/Roche Young Investigator Award. Southeastern Organ Procurement
Foundation. 2001

Fellowships

External Grants:

National Institutes of Health (NIH)
University of Michigan
07/11/2003-01/31/2004
Protocol: DK 57577-1 VCU# 02131
Sub-Investigator. Fund $1,500,000.00
Observational database on patients who receive orthotopic liver transplantation
for hepatitis B.

National Institutes of Health (NIH)
Anna Lok, M.D.
8/2/2002-present
NIH NIDDK R01DK57577-3 VCU IRB #02194
Sub-Investigator. Fund $600,000.00
Randomized trial of Lamivudine and intra-muscular hepatitis B immune globulin vs. Lamivudine monotherapy as maintenance prophylaxis against recurrent hepatitis B post-liver transplantation in high risk patients.

National Institute of Health (NIH)
Anna Lok, M.D.
8/1/2003-present
NIH NIDDK R01DK57577-2 VCU IRB #02195
Sub-Investigator. Fund $600,000.00
Clinical trial of Lamivudine and peri-operative IV hepatitis B immune globulin in the prevention of recurrent hepatitis B post-liver transplantation in low-risk patients.

Wyeth Pharmaceuticals
02/05
VCU IRB #3655
Principal Investigator. Fund $15,790.00
Apo-lipoprotein genetic polymorphisms as predictors of high risk group for hyperlipidemia in kidney transplant recipients undergoing sirolimus treatment.

Wyeth Pharmaceuticals
06/04
VCU . Granted.
Principal Investigator. Fund $4,500.00

Wako Diagnostics
Richard K. Sterling, MD PI
01/2004 – March 2004
Sub-Investigator. $11,625.00
Wako Diagnostics LiBASys Immunoassay Analyzer Study.

Roche Pharmaceuticals
Project CELL 500
Chronic Allograft Nephropathy
Principal Investigator. $141,309.00
Granted. IRB in progress.

Wyeth Pharmaceuticals
06/05
VCU . Clinical utility of molecular selection in patients with hyperlipidemia and
Sirolimus treatment.
Principal Investigator. Fund $83.000.00 per year ( 2 years)
In Progress.

Isotechnika, Inc.
08/ 05. A Phase II B, randomized, open-label, multi-center, concentration-controlled, safety study of ISA-247 and Tacrolimus (Prograft) in De Novo Renal Transplant Patients.
Principal Investigator. Fund. 150.000.00
In progress

Invited Seminars:

October 1999 “Laparoscopic Surgery of the Spleen”. Post-graduate Annual
Course of Surgery, Santiago del Estero, Argentina.

April 1999 “Hepatic Resections”. Hepatology Society. Hospital of Rio
Cuarto, Cordoba, Argentina.

April 1998 “Laparoscopic Surgery and cost-benefice in a Private Hospital”.
Hospital Privado, Cordoba, Argentina.

April 2001 “Transplantation and Tolerance”. Grand Rounds of Medicine.
Catholic University of Cordoba. Cordoba, Argentina.

February 2002 “Immunobiology of chronic rejection in transplantation”. Catholic
University of Cordoba. Cordoba, Ar*gentina.

May 31-2002 “Non-resective ablation therapy plus liver transplantation in
Patients with cirrhosis and HCC”. Research Day. Department of
Surgery, Virginia Commonwealth University Medical Center, Richmond,
VA.

June 2004 “Liver Transplantation at VCUHS: Update in Liver Transplantation”.
Southside Regional Medical Center, Petersburg, VA.

March 2005 “Treatment of Hepatocellular Carcinoma”. 8th Virginia Symposium of
Gastroenterology.

April 5, 2005 “Liver Transplantation at VCUHS: Hepatocellular Carcinoma”. Southside
Regionsal Medical Center, Petersburg, VA.

April 6, 2005 “Liver Transplantation at VCUHS: Hepatocellular Cardinoma:. John
Randolph Medical Center, Hopewell, VA.

MAJOR COMMITTEES:

University
2002 – present M3 Clerkship
2002 – present Liver Transplantation Recipient Selection Committee
2002 – present Kidney/Pancreas Committee
2002 – present Liver Recipient Selection, Living Donor Liver Transplantation Committee

Professional – panels, boards, councils

OTHER SIGNIFICANT SCHOLARLY, RESEARCH OR ADMINISTRATIVE EXPERIENCE:

Graduate students trained

Postdoctoral trainees

RESEARCH EXPERIENCE:

Research Hepatocytes Laboratory. Department of Surgery, Medical College of Virginia Hospitals of Virginia Commonwealth University, Richmond, Virginia.

Molecular Biology Laboratory. Department of Surgery, Medical College of Virginia Hospitals of Virginia Commonwealth Univeristy, Richmond, Virginia.

Microsurgery in small animal models (rat-rabbits). Transplant Research Laboratory. Department of Surgery, Medical College of Virginia Hospitals of Virginia Commonwealth University, Richmond, Virginia

Animal Surgery: Transplant Nephrectomy and liver transplantation in swine model
Catholic University of Cordoba- Argentina.1998-2000.

Laparoscopic Instructor CUEL. Laparoscopic nephrectomy and other procedures swine model.
Catholic University of Cordoba- Argentina.1998-2000.

CLINICAL FELLOWSHIPS:

David Salzberg, M.D. 2005- present.
Inbo Shim, M.D., 7/2004-2005
David Leonard-Vidal, M.D., 10/2002 – 6/2004

Major teaching assignments

Teaching Conference Director
Fellowship Co-Director

BIBLIOGRAPHY:

Papers Published

1. Maluf D, Miranda E, Eynard H, Mondino J.C. Use of antibiotics in laparoscopic
surgery. Experiencia Medica. Cordoba, Argentina. May 1997.

2. Maluf D, Obeide L, Mondino JC. Hepatectomies. Experiencia Medica. Cordoba.
Argentina. Nov. 1998.

3. Maluf D, Mondino JC, Defago V. Conjoined twins and hepatic surgery.
Experiencia Medica. Cordoba, Argentina. Sep 1999.

4. V Defago, Maluf D, Vilarrodona H, Landa L. Morgagni. Hernia in children. Laparoscopic treatment. Cirugia Pediatrica 2000. Vol 7;2: 63-66. Argentina.

5. Mas V, Alvarellos T, Maluf DG, Ferreira-Gonzalez A, Oliveros L, Maldonado R, de Boccardo G. Molecular and Clinical Response to Angiotensin II Receptor Antagonist in Kidney Transplant Patients with Chronic Allograft Nephropathy. International Transplantation, 17(9):540-4. October 2000.

6. Maluf D, Fisher RA, Riley R, Wallace M, Tawes J, Bu D, Posner MP. Immunobiology and long term graft function in a transplant heterotopic renal rat model. Clinical Transplantation Oct; 16 Suppl 7:6-14, 2002.

7. R A Fisher , T Maroney , A Fulcher , D Maluf , J Clay , L Wolf , S Dawson , AH Cotterell , R Stravitz V Luketic , M Shiffman , R Sterling , MP Posner . Hepatocellular Carcinoma: Strategy for optimizing surgical resection, transplantation and palliation. Clinical Transplantation. Oct; 16 Suppl 7:52-8. 2002.

8. DG Maluf, RA Fisher, MP Posner. Hardikar Syndrome. A case requiring liver
transplantation. Transplantation, 74(7): 1058-1061. 2002.

9. Maluf D, Fisher R.A, Dawson S, Cotterell AH, Fulcher A, Tisnado J, Contos M, Luketic V, Stravitz TR, Shiffman M, Posner MP. Non-Resective ablation and liver transplantation in patients with cirrhosis and hepatocellular carcinoma: Safety and Efficacy. AJT, Mar;3(3):312-317. 2003.

10. Mas V, Fisher RA, Maluf D, Wilkinson D, Garrett C, Ferreira-Gonzalez A. Hepatic artery thrombosis alter liver transplantation and genetic factors: prothrombin G20210A polymorphism. Transplantation, 76(1):247-249. 2003.

11. Maluf DG, Rodas E, Fisher RA, Cotterell AH, King AL, Posner MP. Salvage of renal graft after acute torsión following simultaneous kidney-pancreas transplantation. Dialysis & Transplantation, volume 32, number 12. December 2003.

12. R T Stravitz, M Shiffman, A J Sanyal, V A Luketic, R K Sterling, D M Heuman, A Ashworth, A S Mills, M Contos, M P Posner, A Cotterell, D Maluf, R A Fisher. Effects of interferon treatment on liver histology and allograft rejection in patients with recurrent hepatitis C following liver transplantation. Liver Transplantation, 10:850. 2004.

13. Edwards EB, Posner MP, Maluf D, Kauffman HM. Reasons for non-use if recovered kidneys: The effect of donor glomerulosclerosis and creatinine clearance on graft survival. Transplantation, Vol. 77, 1411-1415, No. 9, May 15, 2004.

14. Mas V, Maluf D, Thomson M, Ferreira-Gonzalez A, Fisher RA. Engraftment measurement in human liver tissue after liver cell transplantation by Short Tandem Repeats analysis. Cell Transplantation,. vol. 13, iss. 3, pp. 231-236(6). 2004.

15. Mas V, Fisher RA, Maluf DG, Contos M, Shiffman M, Wilkinson DS, Oliveros L, Garrett CT, Ferreira-Gonzalez A. Polymorphisms (in cytokines and growth factor genes and their association with acute rejection and recurrence oh hepatitis C virus disease in liver transplantation. Clinical Genetics, vol. 65, no. 3, pp. 191-201(11). March 2004.

16. Mas V, Maluf DG, Stravitz R, Clark B, Dumur C, Rodgers C,Ferreira-Gonzalez A, Fisher RA. Hepatocellular Carcinoma in HCV-infected patients awaiting liver transplantation: Genes involved in tumor progression. Liver Transplantation. 10(5):607-20. May 2004.

17. RA Fisher, DG Maluf, L Wolfe, AH Cotterell, T Stravitz, V Luketic, R Sterling, M Shiffman, M Posner. Non-resective ablation therapy for Hepatocellular carcinoma: effectiveness measured by intention-to-treat and dropout from liver transplant waiting list. Clinical Transplant. 18(5):502-12. Oct 2004.

18. DG Maluf, Bradly D, Clark, RA Fisher, AH. Cotterell, MP. Posner. Massive Hepatic artery atherosclerosis of an otherwise suitable donor liver: a case report. Transplant Proc. 36(5):1438-41. June 2004.

19. Shiffman, M.L., R.T. Stravitz, M.J. Contos, R.A. Fisher, A.S. Mills, R.K. Sterling, V.A. Luketic, A.J. Sanyal, A.H. Cotterell, D. Maluf and M.P. Posner. Histologic recurrence of chronic hepatitis C virus in patients following living donor and deceased donor liver transplantation. Liver Transplantation 10: 1248-1255, 2004.

20. Maluf DG, Stravitz RT, Cotterell AH, Posner MP, Nakatsuka M, Behnke M, Shiffman ML, Sterling RK, Luketic VA, Fisher RA. Adult living donor versus deceased donor liver transplantation: A six year single center experience. Am J Transplant. 2005 Jan;5(1):149-56.

21. Maluf DG, Posner MP, Cotterell A H, Fisher RA. Hepatic Angiosarcoma and liver transplantation. Case report and literature review. Transplant Proc. 2005 Jun;37(5):2195-9.

22. Mas V, Maluf G, Archer K, Yanek K, Cotterell A, King A, Gonzalez-Ferreira A, Rodgers C, Fisher RA, Posner M. Study of mRNA Growth Factors in Urinary Cells of Kidney Transplant Recipients as predictors of Chronic Allograft Nephropathy. Transplantation 2005 Dec27

23. Maluf G, Mas V, Archer K, Yanek K, King A, Gonzalez-Ferreira A, Rodgers C, Fisher RA, Posner M. Apolipoprotein E genotypes as predictors of high-risk group for developing hyperlipidemia in kidney transplant recipients undergoing sirolimus treatment. Transplantation 2005 .Dec 27.

24. Mas V, Maluf D, Dumur C, Archer K, Yanek K, Jackson-Cook C, Fisher RA. Molecular techniques for identifying HCC origin and biology after orthotopic liver transplantation . Diagnostic Molecular Pathology (Accepted for publication)

25. Maluf D, Shim I, Posner M, Cotterell AH, Fisher RA. Salvage Procedure for Unexpected Portal Vein Thrombosis in Living-Donor Liver Transplantation. Transplantation Procceding 2006. In Press.

26. Maluf D. Perfluorocarbon-based transplantation Solution fo solid organ
transplantation. In Preparation.

27. Mas V, Maluf D, Yanek K, Cotterell A, King A, Ferreira-Gonzalez A, Fisher RA, and Posner M. Evaluation of urine samples from kidney transplant patients for molecular studies. In Preparation.

Abstracts

1. Maluf D, Mondino JC, Eynard H, Miranda E. Antibiotic Prophilaxis in Laparoscopy. National Meeting of Internal Medicine, November 1993,Rosario,Argentina. Oral Presentation.

2. Maluf D, Mondino JC, Eynard H, Miranda E, Cordoba R. Tumor of Pulmonary Artery. National Meeting of Internal Medicine, November 1993, Rosario, Argentina. Oral presentation.

3. Maluf D, Mondino JC, De Fago V. Coinjoined Twins. Hepatic Surgery. National Meeting of Surgery, Buenos Aires, November 1996.Argentina. Oral presentation.

4. Maluf D, Obeide L, Mondino JC. Hepatic Resections. National Meetings of
Surgery, Buenos Aires, June 1998,Argentina. Oral presentation.

5. Defago V, Maluf D, Vilarrodona H, Landa L. Morgagni. Hernia in newborns. Pediatrics Surgery National Meeting, April 1999, Buenos Aires, Argentina.

6. Maluf D, Courell J. Laparoscopic Treatment of diafragmatic hernias. Pediatrics
Society, may 2000, Buenos Aires, Argentina. Oral presentation.

7. Maluf D, Fisher RA, Riley R, Tawes J, Posner MP. Long Term follow up in a heterotopic rat kidney transplant model with single dose rapamycin. Thomas Starzl meeting. Univ. of Pittsburgh. April 27-28, 2001. Pittsburgh. PA. USA Poster

8. Bu D, Maluf D, Fisher RA. The role of genetically altered transplanted human hepatocyte in the treatment of insulin dependent diabetes mellitus (IDDM). Thomas Starzl meeting. Univ. of Pittsburgh. April 27-28, 2001. Pittsburgh. PA. USA. Poster Presentation.

9. R A Fisher MD, T Maroney MD, A Fulcher MD, D Maluf MD, J Clay MD, L Wolf MS, S Dawson MD, A Cotterell MD, R Stravitz MD, V Luketic MD, M Shiffman MD, R Sterling MD, MP Posner MD. Hepatocellular Carcinoma: Strategy for optimizing surgical resection, transplantation and palliation. Seopf Meeting. San Antonio Texas, 24-25 January 2002.

10. Maluf D, Fisher RA, Riley R, Wallace M, Tawes J, Bu D, Posner MP. Immunobiology and long-term graft function in a transplant heterotopic renal rat model. SEOPF Meeting. S Antonio Texas, 24-25 January 2002 Oral Communication.

11. Maluf D, Fisher RA, Dawson S, Cotterell A, Fulcher A, Tisnado J, Contos M, Luketic V, Stravitz R, Shiffman M, Posner MP. Non-Resective ablation and liver transplantation in patients with cirrhosis and hepatocellular carcinoma: Safety and Efficacy. (Dallas, Texas, February 2002. Fellows meeting) Oral Communication.

12. Mas V, Fisher R, Maluf D, Contos M, Wilkinson D, Garrett C, Ferreira-Gonzalez A. Host genetic factors as predictive markers of outcome after liver transplantation. ASTS. Washington DC. April 2002. Oral presentation.

13. Mas V, Fisher R, Maluf D, Contos M, Wilkinson D, Garrett C, Ferreira-Gonzalez A. Determination of pro-fibrotic, pro-inflammatory genotypes in pre-transplant liver recipients using SNaPSHOT multiplex assay. ASTS. Washington DC. April 2002.Oral presentation.

14. Maluf D, Fisher RA, Contos M, Stravitz R, Mills S, Posner MP. Ablation and liver transplantation in patients with cirrhosis and hepatocellular carcinoma. ASTS. Washington DC. April 2002. Oral presentation.

15. Maluf D, Fisher RA, Pavot DR, Contos M, Stravitz R, Cotterell AH, Anderson M, Posner MP. Histologic indicators of prognosis in hepatocellular carcinoma (HCC) treated with liver transplantation. ASTS. Miami, January 24, 2003. Oral presentation.

16. Cotterell AH, Fisher RA, Wolfe LG, Anderson ML, Maluf D, Stravitz RT, Sterling RK, Luketic VL, Sanyal AJ, Shiffman ML, Posner MP. Comparison of Roux-EN-Y versus duct to duct biliary reconstruction in adult to adult right lobe living donor liver transplantation. ASTS. Washington DC. May 2003. Oral Presentation.

17. Shiffman ML, Fisher RA, Stravitz RT, Luketic VL, Sanyal AJ, Mills AS, Contos MJ, Cotterell AH, Maluf D, Posner MP. Histologic analysis of recurrent hepatitis C virus infection following living donor and cadaveric liver transplantation. ASTS. Washington DC. May 2003. Oral Presentation.

18. Maluf D, Fisher RA, Cotterell AH, Wolfe LG, Shiffman ML, Posner MP. Non-resective ablation for hepatocellular carcinoma: Effectiveness measured by intention-to-treat and dropout from liver waiting list. ASTS. Washington DC. May 2003. Oral Presentation.

19. Stravitz RT, Shiffman ML, Sanyal AJ, Luketic VL, Sterling RK, Ashworth A, Posner MP, Cotterell AH, Maluf D, Mills AS, Contos MJ, Fisher RA. Histologic evaluation of Interferon/Ribavirin therapy in liver transplant recipients with recurrent hepatitis C: Evidence if rejection despite virologic response. ASTS. Washington DC. May 2003.Oral Presentation.

20. Edwards EB, Posner MP, Maulf D, Kauffman HM. Re-Examination of glomerulosclerosis as the primary reason for non-use of recovered cadaveric kidneys. ASTS. Washington DC. May 2003. Oral Presentation.

21. Maluf DG, Stravitz RT, Cotterell AH, Posner MP, Nakatsuka M, Behnke M, Shiffman ML, Sterling RK, Luketic VA, Fisher RA. Adult living donor versus deceased donor liver transplantation: A six year single center experience. ATC. Boston, MA. May 15-19, 2004. Oral Presentation.

22. Valeria R Mas, Daniel G Maluf, Richard Stravitz, Bradly Clark, Catherine I Dumur, Cheryl Rodgers, Andrea Ferreira-Gonzalez, Robert A Fisher. Gene expression patterns in cirrhosis and hepatocellular carcinoma (HCC) in HCV infected patients awaiting liver transplantation. Oral presentation. American Transplant Congress. Boston, MA, May 15-19, 2004.

23. RT Stravitz, P Kimball, VA Luketic, RK Sterling, AJ Sanyal, RA Fisher, AH Cotterell, DG Maluf, MP Posner, SA Mills, M Contos, ML Shiffman. Influence of Class II Human Leukocyte Antigens on Recurrent Hepatitis C and Graft Survival in Liver Transplant Recipients. Oral Presentation. American Transplant Congress. Boston, MA. May 15-19, 2004.

24. Mitsuru Nakatsuka, Daniel Maluf, Adrian Cotterell, Marc Posner. Evaluation of Subcapsular renal cortical tissue blood flow in newly transplanted living donor kidneys assessed by Laser Doppler Flowmetry. Abstract; Poster Presentation. XX International Congress of The Transplantation Society, 5-10 September 2004, Vienna.

25. Mitsuru Nakatsuka, Daniel Maluf, Adrian Cotterell, Marc Posner. Measurement of cardiac output with the esophageal Doppler cardiac function monitor during liver transplantation. Abstract; Poster Presentation. XX International Congress of the Transplantation Society, 5-10 September 2004, Vienna.

26. Yilmaz N, Shiffman ML, Stravitz TR, Sterling RK, Luketic VA, Sanyal AJ, Mills AS, Contos MJ, Maluf D, Cotterell A, Posner MP, Fisher RA. Fibrosis Progression and Graft Loss in Patients with Recurrent HCV Following Liver Transplant (LT): The Impact of Allograft Rejection. Oral presentation 2005 meeting at the Washington State Convention and Trade Center, Seattle, Washington. May 21-25, 2005.

27. Yilmaz N, Shiffman ML, Stravitz TR, Sterling RK, Luketic VA, Sanyal AJ, Mills AS, Contos MJ, Maluf D, Cotterell A, Posner MP, Fisher RA. The Use of Older Donors is Associated With Reduced Survival But Does Not Worsen The Severity of Recurrent HCV Following Liver Transplantation (LT). Oral Presentation at the American Transplant Congress 2005 meeting at the Washington State Convention and Trade Center, Seattle Washington May 21-25, 2005.

28. Hung PD, Shiffman ML, Stravitz TR, Sterling RK, Luketic VA, Sanyal AJ, Mills AS, Contos MJ, Maluf DG, Cotterell AH, Posner MP, Fisher RA. Liver Transplant Complications II, Monday May 25, 2005. Progression of Hepatic Sarcoidosis To Cirrhosis and The Impact of Liver Transplantation. (LT) Oral Presentation at the American Transplant Congress 2005 meeting at the Washington State Convention Center, Seattle WA, May 21-25, 2005

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