Research studies

Patient studies

A2ALL Cohort Study Retrospective Research ­­– A2ALL-Retro-01

Major goals: The primary objective of this arm of the study is to determine whether the decision to undergo living-donor liver transplant is beneficial for the patients who choose the treatment.
Principal investigator: Robert A. Fisher, M.D.
Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases/National Institutes of Health (2002-present)

A2ALL Patient Safety Systems Improvements in Living Donor Liver Transplantation – 1R01DK090129

Major goals: This study proposes to adopt the same systematic, prospective approaches routinely used in other high-risk industries, to living-donor liver transplant processes and systems of care. The systematic and proactive identification of potential weaknesses will permit the development and implementation of solutions and thus reduce medical errors and preventable complications in LDLT.
Principal investigator: Robert A. Fisher, M.D.
Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases/ National Institutes of Health /DHHS (via Northwestern University: 2012-present)

Genes Related to HCC Progression in LD and DD Transplant – 1R01DK069859-01A2

Major goals: To study HCV-HCC initiation and to identify a set of significant genes for classifying high-risk patients with a potential for developing HCC; to analyze disease progression, establishing a molecular fingerprint for distinguishing HCV-HCC patients awaiting a donor with the greatest risk for developing HCC recurrence; to study the aforementioned molecular fingerprint to predict outcomes post-LT by performing survival analysis and comparing the risk of post-LT HCC recurrence stratified by LDLT and deceased-donor liver transplant groups.
Principal investigator: Robert A. Fisher, M.D.
Sponsor: (National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Diseases: 2006-2012), Irvin Liver Transplant Research Fund

Hume-Lee Tissue Bank (Formerly Liver Tissue Cell Procurement and Distribution System – N01DK70004)

Major goals: To collect, store and distribute normal and diseased liver tissue and polycystic kidney tissue to researchers worldwide (2007-present)
Principal investigator: Robert A. Fisher, M.D.
Sponsor: NIH (2007-12), Irvin Liver Transplant Research Fund

Hepatic Regeneration in Donors and Recipients following Living Donor Liver Transplantation

Major goals: To evaluate regeneration of liver tissue in both recipients and donors of transplanted livers.
Principal investigator: Robert A. Fisher, M.D.
Sponsor: Irvin Liver Transplant Research Fund

Studies of Pediatric Liver Transplantation (SPLIT): A Multi-Center Prospective Study to Collect Scientific Data on Pediatric Liver Transplantation (2001-present)

Major goals: This study is comprised of a community of liver care centers whose goal is to increase the knowledge doctors have about current treatment for liver disease and liver transplants in children. Data is collected on patient graft survival, incidents of rejection, growth, immunosuppressants, risk factors, mortality and morbidity.
Principal investigator: Robert A. Fisher, M.D.
Sponsor: The SPLIT Data Coordinating Center, EMMES Corp.

Transplant Registry

Major goals: To compile data on patients with conditions relating to, or leading to, transplantation. This IRB-approved database has been invaluable in evaluating efficacy of treatments and in the publication of papers for professional journals.
Principal investigator: Robert A. Fisher, M.D.
Sponsor: Irvin Liver Transplant Research Fund

An Historical-Cohort, Multi-center, Observational Study to Identify and Characterize Calcineurin Inhibitor Usage Patterns Post-Transplant and Impact Allograft Outcome (CNI Switching Chart Review) – Protocol IM103-155

Principal investigator: Anne King, M.D.
Sponsor: Bristol-Myers Squibb

Animal model studies

Organ Transplant Tolerance Studies (1992–present) – IACUC #AM10096

Major goals: Explore those aspects of physiology and immunobiology as they relate to the transplantation of both cells and solid organs. Currently, we are studying tolerance induction in kidney transplants. We have examined the effect of percutaneous, pulsed, near-infrared light on hepatic regeneration. Studies utilize small animal models (rats and mice).
Principal investigator: Robert A. Fisher, M.D.
Sponsor: Irvin Liver Transplant Research Fund

Allogenic and Xenogenic Hepatocyte and Stem Cell Transplantation to Rescue an Animal Model of Liver Failure – IACUC #AD10000635

Major goals: Using a well-known mouse and rat model for liver failure, we hope to develop an assay for testing the viability of hepatocytes and their ability to rescue an animal from terminal liver failure.
Principal investigator: Robert A. Fisher, M.D.
Sponsor: Irvin Liver Transplant Research Fund

Strategies to Improve Outcomes after Pancreatic Islet and Stem Cell Transplantation in Rodent Model – IACUC #AD10000785

Major goals: Cell transplantation is advantageous in liver failure and refractory fragile diabetes. Cell transplantation is limited by the shortage of whole organs for primary cell extraction. We investigate the ability to generate islet-like and hepatocyte-like cells from alternative cell sources that include induced pluripotent and mesenchymal stem cells. Using animal models of organ failure, we aim to optimize the conditions for transplantation.
Principal investigator: Amit Sharma, M.D.
Sponsor: Irvin Liver Transplant Research Fund