Adult to Adult Living Donor Liver Transplantation Cohort Study

Sponsored by the National Institutes of Health, this is a multi-center, five year study of both living liver donors and their recipients . It includes a retrospective arm that will entail extensive data retrieval and a prospective arm to track patient progress. There is a sub-study, written by Dr. Robert Fisher and Dr. Valeria Mas that will study Hepatocellular Carcinoma on the molecular level in this patient population as well.

Dr. Robert A. Fisher and Dr. Mitchell Shiffman are Co-Principal Investigators in this study.

Hepatic Regeneration in Donors and Recipients following Living Donor Liver Transplantation

This study is to evaluate regeneration of liver tissue in both recipients and donors of transplanted livers. It includes, for example, determination of which factors are most critical to regeneration, to discover markers that will parallel normal regeneration and the relationships that may occur between regeneration and growth factors.

Dr. Robert A. Fisher is the Principal Investigator

The Use of Human Hepatocyte Transplantation as a Life support Bridge in Terminal Liver Failure

The purpose of this research is to gain knowledge about the result of infusing liver cells, carefully matched to blood type, into a subject's body. The hope is that is procedure will aid functions of the liver and prevent death, enable a transplant procedure to be carried out if a donated liver becomes available and lessen complications in postoperative recovery.

Dr. Robert A. Fisher is the Principal Investigator

Liver Tissue Procurement and Distribution System (LTPADS)

This NIH sponsored program is in place to procure, store and distribute normal and diseased liver tissue to researchers worldwide .

Dr. Robert A. Fisher is the Principal Investigator

Studies of Pediatric Liver Transplantation ( SPLIT ), A Multicenter Prospective Study to Collect Scientific Data on Pediatric Liver Transplantation

This NIH sponsored study is designed to help the transplant community better understand the problems and potential solutions surrounding liver transplantation in children . Data is collected on patient graft survival, incidents of rejection, growth, immunosuppressants , risk factors, mortality and morbidity. The data is periodically analyzed and shared with the community.

Dr. Robert A. Fisher is the Principal Investigator

Contact: Michael Akeampong , R.N.
(804) 828-4104

Transplant Registry

The Transplant Registry is an IRB approved data base with information gathered from medical records of patients with conditions relating or leading to transplantation . This data base has been invaluable in evaluating efficacy of treatments and in the publication of papers for professional journals.

Dr. Robert Fisher is the Principal Investigator

A Randomized, Controlled, Multicenter Study of Thymoglobulin Induction Therapy with a Calcineurin -Inhibitor Sparing Regimen in Liver Transplant Patients

This study, sponsored by Genzyme is to explore the safety and efficacy of Thymoglobulin induction therapy in liver transplant patients with renal dysfunction when used with a tacrolimus (TAC)- sapring maintence therapy regimen compared to a TAC-based standard therapy regimen without induction. It is also to explore the impact of Thymoglobulin induction theapy with a TAC-sparing regimen on renal function after transplant.

Dr. Robert Fisher is Principal Investigator